What are the possibilities of a 21-year-old woman conceiving a child with a 43-year-old man?

I had a miscarriage 4 years ago and have irregular periods. My partner, a 43-year-old-man, has 2 older children but we'd like to try again soon. I would also like to know if there would be more chances of something being wrong with the child since he is much older.

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