Does Clomid Work to Cause Ovulation in Women with PCOS?

PCOS or polycystic ovary syndrome is a common cause of infertility in women in their reproductive years. The condition cannot be fully treated, but to increase the chances of conceiving, fertility doctors will prescribe medications such as Clomid to induce ovulation. While Clomid works for many women who get this treatment, it may be ineffective for others.

Clomid in Women with PCOS

Clomid is a drug that induces ovulation and works in over seven out of 10 women that receive this type of treatment. However, if the patient has PCOS, Clomid resistance may occur. Some patients with PCOS respond well to Clomid. Typically, women that develop Clomid resistance include:

  • Insulin resistant women with PCOS
  • Women with PCOS and hyperandrogenic levels (elevated levels of male hormones)
  • Patients with a body mass index (BMI) of over 25
  • Patients with hyperprolactinemia, who require treatment to be able to respond to Clomid

The causes of Clomid resistance may also be idiopathic. There are a few options for women that develop Clomid resistance. The dose can be increased or the fertility doctor can recommend a stronger type of treatment with gonadotropin injections. Overweight patients may get recommendations on how to lose some weight.

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